Genomic investigation of clinically significant coagulase-negative staphylococci

Introduction. Coagulase-negative staphylococci have been recognized both as emerging pathogens and contaminants of clinical samples. High-resolution genomic investigation may provide insights into their significance. Aims. To review the literature regarding coagulase-negative staphylococcal infection utility methods to aid diagnosis management, identify promising areas for future research. Methodology. We searched Google Scholar with terms ( Staphylococcus ) AND (sequencing OR (infection)). prioritized papers that addressed staphylococci, analysis, or infection. Results. A number studies investigated specimen-related, phenotypic genetic factors associated colonization, virulence, but remains problematic. Conclusion. Genomic provides diversity natural history colonization Such information allows development new methodologies compare relatedness predict antimicrobial resistance. Future employ suitable sampling frames coupled application high-resolution whole-genome sequencing more discriminatory diagnostic approaches coagulase-staphylococcal